Preheat oven to 325°F.
Thoroughly dry eye round once out of package.
Heat avocado oil in a Dutch oven on medium heat. While Dutch oven heats up massage dry rub onto eye round.
Sear all sides of roast, 2 minutes per side. Total searing time 12 minutes.
Remove seared roast from Dutch oven and place on a dish. Turn heat down to medium-low and add onions.
Saute onions for 3 minutes deglaze with red wine. Let reduce by half.
Add salsa to onions and cook for 2 minutes.
Place eye round back in Dutch oven along with any juices that may have released from the roast.
Place lid on and put in oven for 2 hours.
Let the roast rest in the covered Dutch oven for 8 minutes once removing from oven. Slice and serve with rice and beans or just a simple salad. Enjoy!